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Food Addiction Institute
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STUDIES

Despite a large amount of promising preclinical results, we did not observe any PFS or OS benefit in the KD-IF group. Several reasons might be responsible for the lacking efficacy of KD-IF. First, the study population might have been too small to detect differences between the two intervention groups. In this regard it is worth noting that we achieved our target of 30% PFS6 in the patients of the intervention group who responded with a drop of glucose to the KD-IF. While overall the groups were well balanced, more patients pretreated with bevacizumab were randomized into the KD-IF group (6 vs. 3) and more patients in the control group had received resections for recurrent tumor prior to study treatment (8 vs. 2)
Food addiction is an emerging area of both clinical and research interest. The current review discussed several definitional and conceptual categorisations that have been put forth to quantify food addiction. However, the YFAS 2·0 concept predominates the literature. Similarly, evidence shows some similarities of food addiction with established eating disorders, particularly BED. Thus, the current review supports two main areas of contention that warrant much more research; considering food addiction as a substance-related addiction or a behavioural-related addiction and if food addiction is distinct from established eating disorders. Further research is needed to continue to delineate and clarify controversies about similarities and differences in food addiction with other concepts and established disorders.
Prospective Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma
Voss M, Wagner M, von Mettenheim N, Harter PN, Wenger KJ, Franz K, Bojunga J, Vetter M, Gerlach R, Glatzel M, Paulsen F, Hattingen E, Baehr O, Ronellenfitsch MW, Fokas E, Imhoff D, Steinbach JP, Rödel C, Rieger J. ERGO2: A Prospective, Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma. Int J Radiat Oncol Biol Phys. 2020 Nov 15;108(4):987-995. https://doi.org/10.1016/j.ijrobp.2020.06.021 Epub 2020 Jun 30. PMID: 32619561
Prospective Randomized Trial of Calorie-Restricted Ketogenic Diet and Fasting in Addition to Reirradiation for Malignant Glioma

20 patients completed the KD-IF and 22 patients the SD as specified by the protocol from 50 recruited patients; Sample size was calculated to detect an increase of PFS6 from 0% (28) to 30% with a power of 80%, necessitating the recruitment of 50 patients in this trial with an anticipated drop-out rate of 8 patients. Inclusion criteria were: recurrence of a histologically confirmed glioblastoma, gliosarcoma or malignant progression of a lower grade glioma on MRI; age above 18 years; Karnofsky performance score (KPS) ≥60%; prior radiation therapy of the tumor at least 6 months before inclusion; prior therapy with temozolomide; multidisciplinary tumor board recommendation for re-irradiation; adequate hematologic, hepatic, renal and coagulatory function

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